Mouse Model Project 1

Lay Abstract

Generating and investigating in vivo PolG mouse models to unravel the mechanistic pathogenesis of PolG-related disorders.


Università di Padova, Italy.

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Principle Investigator

Carlo Viscomi, Ph.D.

Carlo Viscomi is associate professor of biomedical sciences at the Università di Padova. In his work, he has explored numerous strategies to fight mitochondrial diseases and in recent work, Carlo has established the first mouse models for disease-causing mutations in the mitochondrial DNA polymerase (PolG). These models are now used to understand disease progression and probe ways to cure affected patients. Carlo’s work can be found published in journals such as Nature Medicine, Nucleic Acids Res. and EMBO Molecular Medicine. He holds a Ph.D. in physiology from the University of Milano and conducted postdoctoral training at the I.R.C.C.S. IstitutoNeurologicoC.Besta in Milano.

Collaborators in University of Gothenburg
Maria Falkenberg, Ph.D.

Collaborators in Università di Padova
Massimo Zeviani, Ph.D.

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