Mouse Model: C57BL/6N-Polgem5Lutzy/Mmjax Common Name: PolgR292C

Lay Abstract

CRISPR/Cas9 endonuclease mediated genome editing of polymerase (DNA directed), gamma (Polg) was used to introduce an amino acid substitution at position 292 altering arginine to cysteine (R292C). The mutation is homologous to human R309C. This strain may be useful for studies of Polg-associated mitochondrial disorders. 

The mouse model (huPolgR309C) is now available: 

https://www.jax.org/strain/037610

and  

https://www.mmrrc.org/catalog/sds.php?mmrrc_id=71656  

For more information please do not hesitate to contact research@polgfoundation.org

 

Institution

Institution

The Jackson Laboratory

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The Foundation aims to be a leading funder of basic, translational and clinical PolG research. Working with the global scientific community, we are investing in developing critical tools.