Brian Tseng

As a board-certified M.D., Ph.D. pediatric neurologist/neuromuscular physician–scientist, Brian Tseng has led large cross-functional teams (Novartis, AveXis, Vertex) to develop and bring forward many new medicines approved for use in infants and children with rare disorders, in particular genetic disorders. As a retired vice president from two top R&D companies, he has deep experience in translational and clinical development of novel molecules (small, biologic, cell-based, AAV genetic replacement, and CRISPR-mediated gene editing) for children. He is currently an expert consultant with NDA Partners, LLC. His most recent clinical/academic practice has been at Massachusetts General Hospital/Harvard Medical School; he was previously at Children's Hospital Colorado. His physiology undergraduate degree is from University of California Berkeley and he has a Ph.D. in molecular biology from MD Anderson Cancer Center/University of Texas at Houston McGovern Medical School.

Dr. Tseng also teaches in several medical schools, including at the Gates Foundation University of Siena, and volunteers on several boards of nonprofit patient advocacy foundations. He is on the Board of Directors for the Estes Valley Fire Protection District in Colorado. He is also a NOLS Wilderness Medicine first responder.

Our Mission

The mission of The POLG Foundation is to support and accelerate research to find effective treatments and a cure for PolG-related mitochondrial disorders.


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